Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic data.

ABSTRACT:

Motivation

The phenotypes of knockout mice provide crucial information for understanding the biological functions of mammalian genes. Among various knockout phenotypes, lethality is of great interest because those involved genes play essential roles. With the availability of large-scale genomic data, we aimed to assess how well the integration of various genomic features can predict the lethal phenotype of single-gene knockout mice.

Results

We first assembled a comprehensive list of 491 candidate genomic features derived from diverse data sources. Using mouse genes with a known phenotype as the training set, we integrated the informative genomic features to predict the knockout lethality through three machine learning methods. Based on cross-validation, our models could achi

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC3338016 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature