Proteus: a web-based, context-specific modelling tool for molecular networks.

ABSTRACT:

Summary

Molecular networks are often studied in diverse cellular or experimental contexts, with highly context-specific details. Modelling introduces further choices as to levels of mathematical description. The resulting possibilities are difficult to explore rapidly, hampering the integration of modelling and experiment. We have developed Proteus, a web-based, context-specific tool for building compartmentalized, ordinary differential equation (ODE) models. It is inspired by the idea of a molecular 'toolkit' for Ca(2+) signalling. Toolkits in Proteus are context-independent representations of biological systems as sets of components, which may correspond to mechanisms of differing levels of complexity. Users pick and choose components from a toolkit and, for each component, pick

SUBMITTER: Gnad F 

PROVIDER: S-EPMC3338017 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature