Reduced neurobehavioral impairment from sleep deprivation in older adults: contribution of adenosinergic mechanisms.

ABSTRACT: A night without sleep is followed by enhanced sleepiness, increased low-frequency activity in the waking EEG, and reduced vigilant attention. The magnitude of these changes is highly variable among healthy individuals. Findings in young men of low and high subjective caffeine sensitivity suggest that adenosinergic mechanisms contribute to inter-individual differences in sleep deprivation-induced changes in EEG theta activity, as well as optimal performance on the psychomotor vigilance task (PVT). In comparison to young subjects, healthy adults of older age typically feel less sleepy after sleep deprivation, and show fewer response lapses, and faster reaction times on the PVT, especially in the morning after the night without sleep. We hypothesized that age-related changes in adenosine sign

SUBMITTER: Landolt HP 

PROVIDER: S-EPMC3338069 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature