MUC2 polymorphisms are associated with endometriosis development and infertility: a case-control study.

ABSTRACT:

Background

Mucins are highly glycosylated proteins protecting and lubricating epithelial surface of respiratory, gastrointestinal and reproductive tracts. Members of the mucin protein family have been suggested to play an important role in development of endometriosis and infertility. This study investigates genetic association of mucin2 (MUC2) with the risk of endometriosis and endometriosis-related infertility.

Methods

This case-control study was conducted at China Medical University Hospital, with 195 endometriosis patients and 196 healthy controls enrolled. Genotyping of six SNPs (rs2856111, rs11245936, rs10794288, rs10902088, rs7103978 and rs11245954) within MUC2 gene were performed by using Taqman genotyping assay; individual SNP and haplotype associations with endomet

SUBMITTER: Chang CY 

PROVIDER: S-EPMC3338096 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature