Ontology highlight
ABSTRACT:
SUBMITTER: Berger SB
PROVIDER: S-EPMC3338319 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Nature immunology 20100905 10
Phagocytosis is a pivotal process by which macrophages eliminate microorganisms after recognition by pathogen sensors. Here we unexpectedly found that the self ligand and cell surface receptor SLAM functioned not only as a costimulatory molecule but also as a microbial sensor that controlled the killing of gram-negative bacteria by macrophages. SLAM regulated activity of the NADPH oxidase NOX2 complex and phagolysosomal maturation after entering the phagosome, following interaction with the bact ...[more]