Different effects of farrerol on an OVA-induced allergic asthma and LPS-induced acute lung injury.

ABSTRACT:

Background

Farrerol, isolated from rhododendron, has been shown to have the anti-bacterial activity, but no details on the anti-inflammatory activity. We further evaluated the effects of this compound in two experimental models of lung diseases.

Methodology/principal findings

For the asthma model, female BALB/c mice were challenged with ovalbumin (OVA), and then treated daily with farrerol (20 and 40 mg/kg, i.p.) as a therapeutic treatment from day 22 to day 26 post immunization. To induce acute lung injury, female BALB/c mice were injected intranasally with LPS and treated with farrerol (20 and 40 mg/kg, i.p.) 1 h prior to LPS stimulation. Inflammation in the two different models was determined using ELISA, histology, real-time PCR and western blot. Farrerol significantly r

SUBMITTER: Ci X 

PROVIDER: S-EPMC3338508 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature