The dopamine D2 receptor gene in lamprey, its expression in the striatum and cellular effects of D2 receptor activation.

ABSTRACT: All basal ganglia subnuclei have recently been identified in lampreys, the phylogenetically oldest group of vertebrates. Furthermore, the interconnectivity of these nuclei is similar to mammals and tyrosine hydroxylase-positive (dopaminergic) fibers have been detected within the input layer, the striatum. Striatal processing is critically dependent on the interplay with the dopamine system, and we explore here whether D2 receptors are expressed in the lamprey striatum and their potential role. We have identified a cDNA encoding the dopamine D2 receptor from the lamprey brain and the deduced protein sequence showed close phylogenetic relationship with other vertebrate D2 receptors, and an almost 100% identity within the transmembrane domains containing the amino acids essential for dopamine

SUBMITTER: Robertson B 

PROVIDER: S-EPMC3338520 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature