Proteome-wide analysis of functional divergence in bacteria: exploring a host of ecological adaptations.

ABSTRACT: Functional divergence is the process by which new genes and functions originate through the modification of existing ones. Both genetic and environmental factors influence the evolution of new functions, including gene duplication or changes in the ecological requirements of an organism. Novel functions emerge at the expense of ancestral ones and are generally accompanied by changes in the selective forces at constrained protein regions. We present software capable of analyzing whole proteomes, identifying putative amino acid replacements leading to functional change in each protein and performing statistical tests on all tabulated data. We apply this method to 750 complete bacterial proteomes to identify high-level patterns of functional divergence and link these patterns to ecological ad

SUBMITTER: Caffrey BE 

PROVIDER: S-EPMC3338524 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature