Reversible disruption of pre-pulse inhibition in hypomorphic-inducible and reversible CB1-/- mice.

ABSTRACT: Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness only some aspects of the pathology can be represented (endophenotypes). Genetically modified mice are currently being used to obtain or characterize such endophenotypes. Since its cloning and characterization CB1 receptor has increasingly become of significant physiological, pharmacological and clinical interest. Recently, its involvement in schizophrenia has been reported. Among the different approaches employed, gene targeting permits to study the multiple roles of the endocannabinoid system using knockout ((-/-)) mice represent a powerful model but with some limitations due to compensation. To overcome such a limitation, we have generated an inducible and reversi

SUBMITTER: Marongiu MF 

PROVIDER: S-EPMC3338749 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature