YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.

ABSTRACT:

Background

Tissue development and organ growth require constant remodeling of cell-cell contacts formed between epithelial cells. The Hippo signaling cascade curtails organ growth by excluding the transcriptional co-activator Yes Associated Protein 1 (YAP1) from the nucleus. Angiomotin family members recruit YAP1 to tight junctions [1], but whether YAP1 plays a specific role outside of the nucleus is currently unknown.

Methodology/principal findings

The present study demonstrates that the E3 ubiquitin ligase Nedd4.2 targets Angiomotin-like 1 (AMOTL1), a family member that promotes the formation of epithelial tight junctions, for ubiquitin-dependent degradation. Unexpectedly, YAP1 antagonizes the function of Nedd4.2, and protects AMOTL1 against Nedd4.2-mediated degradation. Y

SUBMITTER: Skouloudaki K 

PROVIDER: S-EPMC3338797 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature