Comparative (meta)genomic analysis and ecological profiling of human gut-specific bacteriophage φB124-14.

ABSTRACT: Bacteriophage associated with the human gut microbiome are likely to have an important impact on community structure and function, and provide a wealth of biotechnological opportunities. Despite this, knowledge of the ecology and composition of bacteriophage in the gut bacterial community remains poor, with few well characterized gut-associated phage genomes currently available. Here we describe the identification and in-depth (meta)genomic, proteomic, and ecological analysis of a human gut-specific bacteriophage (designated φB124-14). In doing so we illuminate a fraction of the biological dark matter extant in this ecosystem and its surrounding eco-genomic landscape, identifying a novel and uncharted bacteriophage gene-space in this community. φB124-14 infects only a subset of closely rel

SUBMITTER: Ogilvie LA 

PROVIDER: S-EPMC3338817 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature