Lifestyle change and mobility in obese adults with type 2 diabetes.

ABSTRACT:

Background

Adults with type 2 diabetes mellitus often have limitations in mobility that increase with age. An intensive lifestyle intervention that produces weight loss and improves fitness could slow the loss of mobility in such patients.

Methods

We randomly assigned 5145 overweight or obese adults between the ages of 45 and 74 years with type 2 diabetes to either an intensive lifestyle intervention or a diabetes support-and-education program; 5016 participants contributed data. We used hidden Markov models to characterize disability states and mixed-effects ordinal logistic regression to estimate the probability of functional decline. The primary outcome was self-reported limitation in mobility, with annual assessments for 4 years.

Results

At year 4, among 2514 adul

SUBMITTER: Rejeski WJ 

PROVIDER: S-EPMC3339039 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature