Trajectories of depression severity in clinical trials of duloxetine: insights into antidepressant and placebo responses.

ABSTRACT:

Context

The high percentage of failed clinical trials in depression may be due to high placebo response rates and the failure of standard statistical approaches to capture heterogeneity in treatment response.

Objective

To assess whether growth mixture modeling can provide insights into antidepressant and placebo responses in clinical trials of patients with major depression.

Design

We reanalyzed clinical trials of duloxetine to identify distinct trajectories of Hamilton Scale for Depression (HAM-D) scores during treatment. We analyzed the trajectories in the entire sample and then separately in all active arms and in all placebo arms. Effects of duloxetine hydrochloride, selective serotonin reuptake inhibitor (SSRI), and covariates on the probability of following a pa

SUBMITTER: Gueorguieva R 

PROVIDER: S-EPMC3339151 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature