Research guidelines in the era of large-scale collaborations: an analysis of Genome-wide Association Study Consortia.

ABSTRACT: Scientific research has shifted from studies conducted by single investigators to the creation of large consortia. Genetic epidemiologists, for example, now collaborate extensively for genome-wide association studies (GWAS). The effect has been a stream of confirmed disease-gene associations. However, effects on human subjects oversight, data-sharing, publication and authorship practices, research organization and productivity, and intellectual property remain to be examined. The aim of this analysis was to identify all research consortia that had published the results of a GWAS analysis since 2005, characterize them, determine which have publicly accessible guidelines for research practices, and summarize the policies in these guidelines. A review of the National Human Genome Research Ins

SUBMITTER: Austin MA 

PROVIDER: S-EPMC3339312 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature