Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.

ABSTRACT:

Background

Epidemiological studies emphasize the possible role of persistent organic pollutants (POPs) in obesity and the metabolic syndrome. These pollutants are stored in adipose tissue (AT).

Objectives

Our aim was to study the effects of POPs on human adipose cells and rodent AT.

Methods

Using human multipotent adipose-derived stem cells, we carried out large-scale gene expression analysis to identify the major pathways modified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyl (PCB) congener 126 (PCB-126), and PCB-153 and to evaluate their toxic effects. The effects of TCDD on gene expression and AT histology were also assessed in mice.

Results

The most significantly regulated genes in both precursor cells and adipocytes were those inv

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC3339464 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature