Dataset Information

Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI.

ABSTRACT:

Context

Cushing's Disease (CD) alters fat distribution, muscle mass, adipokine profile, and cardiovascular risk factors. It is not known whether remission entirely reverses these changes.

Objectives

Our objective was to determine whether the adverse body composition and cardiovascular risk profile in CD change after remission.

Design, setting, and patients

Fourteen CD patients were studied prospectively: before surgery (active disease) and again postoperatively 6 months after discontinuing oral glucocorticoids (remission). Whole-body magnetic resonance imaging was used to examine lean and fat tissue distributions.

Outcome measures

Body composition (skeletal muscle and fat in the visceral, bone marrow, sc, and inter-muscular compartments) and cardiovascular risk factors (serum insulin, glucose, leptin, high-molecular-weight adiponectin, C-reactive protein, and lipid profile) were measured in active CD and remission (mean 20 months after surgery).

Results

Remission decreased visceral, pelvic bone marrow, sc (including trunk and limb sc), and total fat; waist circumference; and weight (P < 0.05). Remission altered fat distribution, resulting in decreased visceral/total fat (P = 0.04) and visceral fat/skeletal muscle ratios (P = 0.006). Remission decreased the absolute muscle mass (P = 0.015). Cardiovascular risk factors changed: insulin resistance, leptin, and total cholesterol decreased (P < 0.05), but adiponectin, C-reactive protein, and other lipid measures did not change.

Conclusions

CD remission reduced nearly all fat depots and reverted fat to a distribution more consistent with favorable cardiovascular risk but decreased skeletal muscle. Remission improved some but not all cardiovascular risk markers. Remission from CD dramatically improves body composition abnormalities but may still be associated with persistent cardiovascular risk.

SUBMITTER: Geer EB

PROVIDER: S-EPMC3339890 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Publications

Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI.

Geer Eliza B EB Shen Wei W Strohmayer Erika E Post Kalmon D KD Freda Pamela U PU

The Journal of clinical endocrinology and metabolism 20120314 5

<h4>Context</h4>Cushing's Disease (CD) alters fat distribution, muscle mass, adipokine profile, and cardiovascular risk factors. It is not known whether remission entirely reverses these changes.<h4>Objectives</h4>Our objective was to determine whether the adverse body composition and cardiovascular risk profile in CD change after remission.<h4>Design, setting, and patients</h4>Fourteen CD patients were studied prospectively: before surgery (active disease) and again postoperatively 6 months aft ...[more]

PMID: 22419708

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Dataset Information

Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI.

Context

Objectives

Design, setting, and patients

Outcome measures

Results

Conclusions

Publications

Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI.

Similar Datasets

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