ISyTE: integrated Systems Tool for Eye gene discovery.

ABSTRACT:

Purpose

To facilitate the identification of genes associated with cataract and other ocular defects, the authors developed and validated a computational tool termed iSyTE (integrated Systems Tool for Eye gene discovery; http://bioinformatics.udel.edu/Research/iSyTE). iSyTE uses a mouse embryonic lens gene expression data set as a bioinformatics filter to select candidate genes from human or mouse genomic regions implicated in disease and to prioritize them for further mutational and functional analyses.

Methods

Microarray gene expression profiles were obtained for microdissected embryonic mouse lens at three key developmental time points in the transition from the embryonic day (E)10.5 stage of lens placode invagination to E12.5 lens primary fiber cell differentiation. Diffe

SUBMITTER: Lachke SA 

PROVIDER: S-EPMC3339920 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature