QTL/microarray approach using pathway information.

ABSTRACT:

Background

A combined quantitative trait loci (QTL) and microarray-based approach is commonly used to find differentially expressed genes which are then identified based on the known function of a gene in the biological process governing the trait of interest. However, a low cutoff value in individual gene analyses may result in many genes with moderate but meaningful changes in expression being missed.

Results

We modified a gene set analysis to identify intersection sets with significantly affected expression for which the changes in the individual gene sets are less significant. The gene expression profiles in liver tissues of four strains of mice from publicly available microarray sources were analyzed to detect trait-associated pathways using information on the QTL regio

SUBMITTER: Matsuda H 

PROVIDER: S-EPMC3340326 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature