Structural and functional changes of the human macula during acute exposure to high altitude.

ABSTRACT:

Background

This study aimed to quantify structural and functional changes at the macula during acute exposure to high altitude and to assess their structure/function relationship. This work is related to the Tuebingen High Altitude Ophthalmology (THAO) study.

Methodology/principal findings

Spectral domain optical coherence tomography and microperimetry were used to quantify changes of central retinal structure and function in 14 healthy subjects during acute exposure to high altitude (4559 m). High-resolution volume scans and fundus-controlled microperimetry of the posterior pole were performed in addition to best-corrected visual acuity (BCVA) measurements and assessment of acute mountain sickness. Analysis of measurements at altitude vs. baseline revealed increased total r

SUBMITTER: Fischer MD 

PROVIDER: S-EPMC3340355 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature