Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system.

ABSTRACT: Functional loads on an organ induce tissue adaptations by converting mechanical energy into chemical energy at a cell-level. The transducing capacity of cells alters physico-chemical properties of tissues, developing a positive feedback commonly recognized as the form-function relationship. In this study, organ and tissue adaptations were mapped in the bone-tooth complex by identifying and correlating biomolecular expressions to physico-chemical properties in rats from 1.5 to 15 months. However, future research using hard and soft chow over relevant age groups would decouple the function related effects from aging affects. Progressive curvature in the distal root with increased root resorption was observed using micro X-ray computed tomography. Resorption was correlated to the increased ac

SUBMITTER: Leong NL 

PROVIDER: S-EPMC3340399 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature