The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use.

ABSTRACT:

Objective

To determine the impact of maternal and fetal single nucleotide polymorphisms in key betamethasone pathways on neonatal outcomes.

Study design

DNA was obtained from women given betamethasone and their infants. Samples were genotyped for 73 exploratory drug metabolism and glucocorticoid pathway single nucleotide polymorphisms. Clinical variables and neonatal outcomes were obtained. Logistic regression analysis using relevant clinical variables and genotypes to model for associations with neonatal respiratory distress syndrome was performed.

Results

One hundred nine women delivering 117 infants were analyzed. Sixty-four infants (49%) developed respiratory distress syndrome. Multivariable analysis revealed that respiratory distress syndrome was associated with

SUBMITTER: Haas DM 

PROVIDER: S-EPMC3340461 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature