Structure-based functional inference of hypothetical proteins from Mycoplasma hyopneumoniae.

ABSTRACT: Enzootic pneumonia caused by Mycoplasma hyopneumoniae is a major constraint to efficient pork production throughout the world. This pathogen has a small genome with 716 coding sequences, of which 418 are homologous to proteins with known functions. However, almost 42% of the 716 coding sequences are annotated as hypothetical proteins. Alternative methodologies such as threading and comparative modeling can be used to predict structures and functions of such hypothetical proteins. Often, these alternative methods can answer questions about the properties of a model system faster than experiments. In this study, we predicted the structures of seven proteins annotated as hypothetical in M. hyopneumoniae, using the structure-based approaches mentioned above. Three proteins were predicted to be

SUBMITTER: da Fonseca MM 

PROVIDER: S-EPMC3340535 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature