Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation.

ABSTRACT:

Introduction

End-stage renal disease (ESRD) is a major public health problem. Although kidney transplantation is a viable therapeutic option, this therapy is associated with significant limitations, including a shortage of donor organs. Induced pluripotent stem (iPS) cell technology, which allows derivation of patient-specific pluripotent stem cells, could provide a possible alternative modality for kidney replacement therapy for patients with ESRD.

Methods

The feasibility of iPS cell generation from patients with a history of ESRD was investigated using lentiviral vectors expressing pluripotency-associated factors.

Results

In the present article we report, for the first time, generation of iPS cells from kidney transplant recipients with a history of autosomal-domina

SUBMITTER: Thatava T 

PROVIDER: S-EPMC3340557 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature