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Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells.

ABSTRACT: Hydrogen sulfide (H(2)S) is an important biological messenger but few biologically-compatible methods are available for its detection. Here we report two bright fluorescent probes that are selective for H(2)S over cysteine, glutathione and other reactive sulfur, nitrogen, and oxygen species. Both probes are demonstrated to detect H(2)S in live cells.

SUBMITTER: Montoya LA 

PROVIDER: S-EPMC3340910 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells.

Montoya Leticia A LA   Pluth Michael D MD  

Chemical communications (Cambridge, England) 20120404 39

Hydrogen sulfide (H(2)S) is an important biological messenger but few biologically-compatible methods are available for its detection. Here we report two bright fluorescent probes that are selective for H(2)S over cysteine, glutathione and other reactive sulfur, nitrogen, and oxygen species. Both probes are demonstrated to detect H(2)S in live cells. ...[more]

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