Carboplatin-associated ototoxicity in children with retinoblastoma.

ABSTRACT:

Purpose

Carboplatin-induced ototoxicity remains poorly defined but is of potential great consequence in children with retinoblastoma. We retrospectively assessed the incidence of ototoxicity and its risk factors in children with retinoblastoma who were treated with carboplatin.

Patients and methods

We reviewed the audiologic test results of 60 patients with retinoblastoma who received front-line treatment with systemic carboplatin and vincristine according to the St Jude RET-3 protocol (n = 23) or best clinical management (n = 37). Ototoxicity was evaluated by three different grading systems.

Results

Twelve patients (20%) developed ototoxicity at some time after treatment initiation; however, ototoxicity resolved in two patients, and thus,10 patients (17%) had sustain

SUBMITTER: Qaddoumi I 

PROVIDER: S-EPMC3341147 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature