Patterns and influencing factor of synonymous codon usage in porcine circovirus.

ABSTRACT:

Background

Analysis of codon usage can reveal much about the molecular evolution of the viruses. Nevertheless, little information about synonymous codon usage pattern of porcine circovirus (PCV) genome in the process of its evolution is available. In this study, to give a new understanding on the evolutionary characteristics of PCV and the effects of natural selection from its host on the codon usage pattern of the virus, Patterns and the key determinants of codon usage in PCV were examined.

Methods

We carried out comprehensive analysis on codon usage pattern in the PCV genome, by calculating relative synonymous codon usage (RSCU), effective number of codons (ENC), dinucleotides and nucleic acid content of the PCV genome.

Results

PCV genomes have relatively much lower

SUBMITTER: Liu XS 

PROVIDER: S-EPMC3341187 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature