Spiroindolines identify the vesicular acetylcholine transporter as a novel target for insecticide action.

ABSTRACT: The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at novel protein binding sites is therefore important for the continued protection of the food supply from insect predators, and of human and animal health from insect borne disease. Here we describe a novel class of insecticides (Spiroindolines) encompassing molecules that combine excellent activity against major agricultural pest species with low mammalian toxicity. We confidently assign the vesicular acetylcholine transporter as the molecular target of Spiroindolines through the combination of molecular genetics in model organisms with a pharmacolo

SUBMITTER: Sluder A 

PROVIDER: S-EPMC3341389 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature