Determining fetal manganese exposure from mantle dentine of deciduous teeth.

ABSTRACT: Studies addressing health effects of manganese (Mn) excess or deficiency during prenatal development are hampered by a lack of biomarkers that can reconstruct fetal exposure. We propose a method using the neonatal line, a histological feature in deciduous teeth, to identify regions of mantle dentine formed at different prenatal periods. Micromeasurements of Mn in these regions may be used to reconstruct exposure at specific times in fetal development. To test our hypothesis, we recruited pregnant women before 20 weeks gestation from a cohort of farmworkers exposed to Mn-containing pesticides. We collected house floor dust samples and mother's blood during the second trimester; umbilical cord blood at birth; and shed deciduous incisors when the child was ∼7 years of age. Mn levels in mantle

SUBMITTER: Arora M 

PROVIDER: S-EPMC3341525 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature