Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory Study.

ABSTRACT:

Background

To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function.

Methods

This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross-sectional associations between medication use and cognitive function.

Results

In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE-I, and 2% AT2RB

SUBMITTER: Yasar S 

PROVIDER: S-EPMC3341535 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature