Accelerating membrane insertion of peripheral proteins with a novel membrane mimetic model.

ABSTRACT: Characterizing atomic details of membrane binding of peripheral membrane proteins by molecular dynamics (MD) has been significantly hindered by the slow dynamics of membrane reorganization associated with the phenomena. To expedite lateral diffusion of lipid molecules without sacrificing the atomic details of such interactions, we have developed a novel membrane representation, to our knowledge, termed the highly mobile membrane-mimetic (HMMM) model to study binding and insertion of various molecular species into the membrane. The HMMM model takes advantage of an organic solvent layer to represent the hydrophobic core of the membrane and short-tailed phospholipids for the headgroup region. We demonstrate that using these components, bilayer structures are formed spontaneously and rapidly,

SUBMITTER: Ohkubo YZ 

PROVIDER: S-EPMC3341550 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature