Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case-control study.

ABSTRACT:

Objectives

The irreversible airflow limitation characterised by chronic obstructive pulmonary disease (COPD) causes a decrease in the oxygen supply to the brain. The aim of the present study was to investigate brain structural damage in COPD.

Design

Retrospective case-control study. Patients with COPD and healthy volunteers were recruited. The two groups were matched in age, gender and educational background.

Setting

A hospital and a number of communities: they are all located in southern Fujian province, China.

Participants

25 stable patients and 25 controls were enrolled from December 2009 to May 2011.

Methods

Using voxel-based morphometry and tract-based spatial statistics based on MRI to analyse grey matter (GM) density and white matter fractional an

SUBMITTER: Zhang H 

PROVIDER: S-EPMC3341600 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature