Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling.

ABSTRACT:

Rationale

Both nuclear factors of activated T cells (NFAT) and nuclear factor-κB (NFκB) are Rel homology domain (RHD)-containing transcription factors whose independent activities are critically involved in regulating cardiac hypertrophy and failure.

Objective

To determine the potential functional interaction between NFAT and NFκB signaling pathways in cardiomyocytes and its role in cardiac hypertrophy and remodeling.

Methods and results

We identified a novel transcriptional regulatory mechanism whereby NFκB and NFAT directly interact and synergistically promote transcriptional activation in cardiomyocytes. We show that the p65 subunit of NFκB coimmunoprecipitates with NFAT in cardiomyocytes, and this interaction maps to the RHD within p65. Overexpression of the p65-R

SUBMITTER: Liu Q 

PROVIDER: S-EPMC3341669 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature