Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response.

ABSTRACT:

Background

To determine whether office, home, ambulatory daytime and nighttime blood pressure (BP) responses to antihypertensive drug therapy measure the same signal and which method provides greatest power to identify genetic predictors of BP response.

Methods

We analyzed office, home, ambulatory daytime and nighttime BP responses in hypertensive adults randomized to atenolol (N = 242) or hydrochlorothiazide (N = 257) in the Pharmacogenomic Evaluation of Antihypertensive Responses Study. Since different measured BP responses may have different predictors, we tested the "same signal" model by using linear regression methods to determine whether known predictors of BP response depend on the method of BP measurement. We estimated signal-to-noise ratios and compared power to id

SUBMITTER: Turner ST 

PROVIDER: S-EPMC3342146 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature