High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations.

ABSTRACT:

Aims

Hydrogen sulfide (H(2)S) is a signaling molecule, which influences many physiological processes. While H(2)S is produced and degraded in many cell types, the kinetics of its turnover in different tissues has not been reported. In this study, we have assessed the rates of H(2)S production in murine liver, kidney, and brain homogenates at pH 7.4, 37°C, and at physiologically relevant cysteine concentrations. We have also studied the kinetics of H(2)S clearance by liver, kidney, and brain homogenates under aerobic and anaerobic conditions.

Results

We find that the rate of H(2)S production by these tissue homogenates is considerably higher than background rates observed in the absence of exogenous substrates. An exponential decay of H(2)S with time is observed and, as expec

SUBMITTER: Vitvitsky V 

PROVIDER: S-EPMC3342560 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature