Gene expression profiles of the NCI-60 human tumor cell lines define molecular interaction networks governing cell migration processes.

ABSTRACT: Although there is extensive information on gene expression and molecular interactions in various cell types, integrating those data in a functionally coherent manner remains challenging. This study explores the premise that genes whose expression at the mRNA level is correlated over diverse cell lines are likely to function together in a network of molecular interactions. We previously derived expression-correlated gene clusters from the database of the NCI-60 human tumor cell lines and associated each cluster with function categories of the Gene Ontology (GO) database. From a cluster rich in genes associated with GO categories related to cell migration, we extracted 15 genes that were highly cross-correlated; prominent among them were RRAS, AXL, ADAM9, FN14, and integrin-beta1. We then us

SUBMITTER: Kohn KW 

PROVIDER: S-EPMC3343048 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature