Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is characterized by an excessive focus on upsetting or disturbing thoughts, feelings, and images that are internally-generated. Internally-focused thought processes are subserved by the "default mode network" (DMN), which has been found to be hyperactive in OCD during cognitive tasks. In healthy individuals, disengagement from internally-focused thought processes may rely on interactions between DMN and a fronto-parietal network (FPN) associated with external attention and task execution. Altered connectivity between FPN and DMN may contribute to the dysfunctional behavior and brain activity found in OCD.

Methods

The current study examined interactions between FPN and DMN during rest in 30 patients with OCD (17 unmedicated) and

SUBMITTER: Stern ER 

PROVIDER: S-EPMC3343054 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature