Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons.

ABSTRACT: Proper functioning of working memory involves the expression of stimulus-selective persistent activity in pyramidal neurons of the prefrontal cortex (PFC), which refers to neural activity that persists for seconds beyond the end of the stimulus. The mechanisms which PFC pyramidal neurons use to discriminate between preferred vs. neutral inputs at the cellular level are largely unknown. Moreover, the presence of pyramidal cell subtypes with different firing patterns, such as regular spiking and intrinsic bursting, raises the question as to what their distinct role might be in persistent firing in the PFC. Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which o

SUBMITTER: Sidiropoulou K 

PROVIDER: S-EPMC3343116 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature