Biomarker discovery in serum from patients with carotid atherosclerosis.

ABSTRACT:

Background

Blood-based biomarkers of atherosclerosis have been used to identify patients at high risk for developing stroke. We hypothesized that patients with carotid artery disease would have a distinctive proteomic signature in blood as compared to a healthy control population without carotid artery disease. In order to discover protein biomarkers associated with increased atherosclerotic risk, we used two different strategies to identify biomarkers from patients with clinically defined atherosclerosis who were undergoing endarterectomy for atherosclerotic carotid artery disease. These patients were compared with healthy matched controls.

Methods

Serum was obtained from patients undergoing endarterectomy (EA; n = 38) and compared to a group of age-matched healthy controls

SUBMITTER: Degraba TJ 

PROVIDER: S-EPMC3343755 | biostudies-literature | 2011 Jan-Dec

REPOSITORIES: biostudies-literature