Poisson parameters of antimicrobial activity: a quantitative structure-activity approach.

ABSTRACT: A contingency of observed antimicrobial activities measured for several compounds vs. a series of bacteria was analyzed. A factor analysis revealed the existence of a certain probability distribution function of the antimicrobial activity. A quantitative structure-activity relationship analysis for the overall antimicrobial ability was conducted using the population statistics associated with identified probability distribution function. The antimicrobial activity proved to follow the Poisson distribution if just one factor varies (such as chemical compound or bacteria). The Poisson parameter estimating antimicrobial effect, giving both mean and variance of the antimicrobial activity, was used to develop structure-activity models describing the effect of compounds on bacteria and fungi spe

SUBMITTER: Sestras RE 

PROVIDER: S-EPMC3344275 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature