Pavlovian reward prediction and receipt in schizophrenia: relationship to anhedonia.

ABSTRACT: Reward processing abnormalities have been implicated in the pathophysiology of negative symptoms such as anhedonia and avolition in schizophrenia. However, studies examining neural responses to reward anticipation and receipt have largely relied on instrumental tasks, which may confound reward processing abnormalities with deficits in response selection and execution. 25 chronic, medicated outpatients with schizophrenia and 20 healthy controls underwent functional magnetic resonance imaging using a pavlovian reward prediction paradigm with no response requirements. Subjects passively viewed cues that predicted subsequent receipt of monetary reward or non-reward, and blood-oxygen-level-dependent signal was measured at the time of cue presentation and receipt. At the group level, neural resp

SUBMITTER: Dowd EC 

PROVIDER: S-EPMC3344823 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature