Effect of (S)-3,5-DHPG on microRNA expression in mouse brain.

ABSTRACT: MicroRNAs are small non-coding RNAs that regulate post-transcriptional gene expression. In the short time since the discovery of microRNAs, the literature has burgeoned with studies focused on the biosynthesis of microRNAs, target prediction and binding, and mechanisms of translational repression by microRNAs. Given the prominent role of microRNAs in all areas of cell biology, it is not surprising that microRNAs are also linked to human diseases, including those of the nervous system. One of the least-studied areas of microRNA research is how their expression is regulated outside of development and cancer. Thus, we examined a role for regulation of microRNAs by neurotransmitter receptor activation in mouse brain. We focused on the group I metabotropic glutamate receptors by using intracere

SUBMITTER: Lusardi TA 

PROVIDER: S-EPMC3345043 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature