Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma.

ABSTRACT:

Background

Relationships among allergen-specific IgE levels, allergen exposure and asthma severity are poorly understood since sensitization has previously been evaluated as a dichotomous, rather than continuous characteristic.

Methods

Five hundred and forty-six inner-city adolescents enrolled in the Asthma Control Evaluation study underwent exhaled nitric oxide (FE(NO)) measurement, lung function testing, and completion of a questionnaire. Allergen-specific IgE levels and blood eosinophils were quantified. Dust samples were collected from the participants' bedrooms for quantification of allergen concentrations. Participants were followed for 12 months and clinical outcomes were tracked.

Results

Among sensitized participants, allergen-specific IgE levels were correlat

SUBMITTER: Matsui EC 

PROVIDER: S-EPMC3345161 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature