The progression from obesity to type 2 diabetes in Alstrom syndrome.

ABSTRACT:

Background

Alström syndrome (ALMS) is a rare autosomal recessive monogenic disease associated with obesity, hyperinsulinemia, and alterations of glucose metabolism that often lead to the development of type 2 diabetes at a young age.

Objective

To study the relationship between weight and metabolism in a group of ALMS patients and matched controls.

Research design and methods

Fifteen ALMS patients (eight males, seven females; aged 3-51) were compared in a cross-sectional study with an age- and weight-matched control population. Anthropometric parameters, fat mass, glucose and insulin secretion in basal and dynamic oral glucose tolerance test (OGTT) conditions were measured. Furthermore, anthropometric and body composition data were obtained from an international group

SUBMITTER: Bettini V 

PROVIDER: S-EPMC3345208 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature