Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.

ABSTRACT: The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves. Their role in the unconscious regulation of organ and central nervous system function makes them potential therapeutic targets for a broad spectrum of diseases. The M2 muscarinic acetylcholine receptor (M2 receptor) is essential for the physiological control of cardiovascular function through activation of G-protein-coupled inwardly rectifying potassium channels, and is of particular interest because of its extensive pharmacological characterization with both orthosteric and allosteric ligands. Here we report the structure of the antagonist-bound huma

SUBMITTER: Haga K 

PROVIDER: S-EPMC3345277 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature