The progress made in determining the Mycobacterium tuberculosis structural proteome.

ABSTRACT: Mycobacterium tuberculosis is a highly infectious pathogen that is still responsible for millions of deaths annually. Effectively treating this disease typically requires a course of antibiotics, most of which were developed decades ago. These drugs are, however, not effective against persistent tubercle bacilli and the emergence of drug-resistant stains threatens to make many of them obsolete. The identification of new drug targets, allowing the development of new potential drugs, is therefore imperative. Both proteomics and structural biology have important roles to play in this process, the former as a means of identifying promising drug targets and the latter allowing understanding of protein function and protein-drug interactions at atomic resolution. The determination of M. tuberculo

SUBMITTER: Ehebauer MT 

PROVIDER: S-EPMC3345573 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature