Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.

ABSTRACT:

Objective

Several genome-wide association studies (GWAS) have associated variants in late-onset Alzheimer disease (LOAD) susceptibility genes; however, these single nucleotide polymorphisms (SNPs) have very modest effects, suggesting that single SNP approaches may be inadequate to identify genetic risks. An alternative approach is the use of multilocus genotype patterns (MLGPs) that combine SNPs at different susceptibility genes.

Methods

Using data from 1,365 subjects in the National Institute on Aging Late-Onset Alzheimer's Disease Family Study, we conducted a family-based association study in which we tabulated MLGPs for SNPs at CR1, BIN1, CLU, PICALM, and APOE. We used generalized estimating equations to model episodic memory as the dependent endophenotype of LOAD and the

SUBMITTER: Barral S 

PROVIDER: S-EPMC3345618 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature