Echovirus 30 induced neuronal cell death through TRIO-RhoA signaling activation.

ABSTRACT:

Background

Echovirus 30 (Echo30) is one of the most frequently identified human enteroviruses (EVs) causing aseptic meningitis and encephalitis. However the mechanism underlying the pathogenesis of Echo30 infection with significant clinical outcomes is not completely understood. The aim of this investigation is to illustrate molecular pathologic alteration in neuronal cells induced by Echo30 infection using clinical isolate from young patient with neurologic involvement.

Methodology/principal findings

To characterize the neuronal cellular response to Echo30 infection, we performed a proteomic analysis based on two-dimensional gel electrophoresis (2-DE) and MALDI-TOF/TOF Mass Spectrophotometric (MS) analysis. We identified significant alteration of several protein expression

SUBMITTER: Lee JW 

PROVIDER: S-EPMC3346726 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature