Ontology highlight
ABSTRACT:
SUBMITTER: Somma G
PROVIDER: S-EPMC3346896 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Journal of the Association for Research in Otolaryngology : JARO 20120302 3
The head bobber transgenic mouse line, produced by pronuclear integration, exhibits repetitive head tilting, circling behavior, and severe hearing loss. Transmitted as an autosomal recessive trait, the homozygote has vestibular and cochlea inner ear defects. The space between the semicircular canals is enclosed within the otic capsule creating a vacuous chamber with remnants of the semicircular canals, associated cristae, and vestibular organs. A poorly developed stria vascularis and endolymphat ...[more]