Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.

ABSTRACT: Genetic drift of influenza virus genomic sequences occurs through the combined effects of sequence alterations introduced by a low-fidelity polymerase and the varying selective pressures experienced as the virus migrates through different host environments. While traditional phylogenetic analysis is useful in tracking the evolutionary heritage of these viruses, the specific genetic determinants that dictate important phenotypic characteristics are often difficult to discern within the complex genetic background arising through evolution. Here we describe a novel influenza virus sequence feature variant type (Flu-SFVT) approach, made available through the public Influenza Research Database resource (www.fludb.org), in which variant types (VTs) identified in defined influenza virus protein s

SUBMITTER: Noronha JM 

PROVIDER: S-EPMC3347290 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature