The contribution of systemic and pulmonary immune effectors to vaccine-induced protection from H5N1 influenza virus infection.

ABSTRACT: Live attenuated influenza vaccines (LAIVs) are effective in providing protection against influenza challenge in animal models and in preventing disease in humans. We previously showed that LAIVs elicit a range of immune effectors and that successful induction of pulmonary cellular and humoral immunity in mice requires pulmonary replication of the vaccine virus. An upper respiratory tract immunization (URTI) model was developed in mice to mimic the human situation, in which the vaccine virus does not replicate in the lower respiratory tract, allowing us to assess the protective efficacy of an H5N1 LAIV against highly pathogenic H5N1 virus challenge in the absence of significant pulmonary immunity. Our results show that, after one dose of an H5N1 LAIV, pulmonary influenza-specific lymphocyte

SUBMITTER: Lau YF 

PROVIDER: S-EPMC3347357 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature